I can't really put it in another slot since I have 3 GTX 480's installed but before I got my 3rd 480 I had tried it in another slot and it grabed the same IRQ. Sounds like I'm stuck with 16 for the sound card. In regards to having any problems. I can't say that I am but I really don't like the idea of 3 video cards, USB host controller, and a sound card fighting for the same IRQ. It would give me peace of mind to seperate the sound card.