hmm... you updated your bios? and now no harddrive light? perhaps a bad flash on the bios?
did the new bios fix other specific problems you were having?
You may want to include your system specs in your signature.
that way others looking at this thread will have a better idea about your system.
Maybe someone else with the same board has had a similar problem.
be sure to include the full specs on your power supply
brand, wattage, & amps for 3.3v,5v& 12v rail(s)
(on a sticker on the side of your psu.)
PS. I just noticed this thread, not quite the same problem, but close:https://forum-en.msi.com/index.php?topic=122733.0